Wow – the title of this alone has brought in comments. Here’s my thinking:
Shuffling is the worst part of deckbuilders. It’s annoying, it takes time, it can damage your cards, and worst of all, it gets people into interminable sleeve vs no-sleeve debates. Nevertheless, randomizing purchased cards is at the heart of the deckbuilding genre. If you get rid of it in favor of a no-shuffle approach, you’re really building a whole new kind of game – a deck-sequencing game.
A deck-builder with no shuffling needs to address a few things: how can cards change sequence, and how can the game retain interest if you keep playing the same cards in the same order. I have a few thoughts on the matter, but it will have to wait for another post.